Vozianova S.V. Clinical-pathogenetic peculiarities of formation and course of rosacea in men and women, their comparative characteristics, and elaboration of differentiated treatment scheme. A manuscript. Dissertation for application for a scientific grade “Doctor of Medical Sciences”, specialty 14.01.20 – skin and venereal diseases. –  State Establishment ”Institute of Dermatology and Venereology of Academy of Medical Sciences of Ukraine”, Kharkiv, 2008.

The dissertation work is devoted to solution of a scientific problem concerning increase of treatment efficacy of patients suffering from rosacea, taking into account pathophysiological, morphological, hormonal, and immunological changes.

It has been established that rosacea clinical course   has certain peculiarities, caused by gender differences, in changes of hormonal homeostasis, blood circulation system, concomitant diseases. Systemic nature of blood circulation has been proven.

Activation of neoangiogenesis processes has been revealed using immunohistochemical, electron microscopy, and morphometric methods in inflammatory form of rosacea; intensification of proliferation processes in epidermis cells and derma among patients with rhinophyma.

An original treatment method for rosacea patients has been elaborated; it uses phlebodia (600), cratal  erbisol. Therapeutic effect has been achieved in 77.6 – 83,3 % of the patients.

Key words: rosacea, etiological pathogenesis, clinical course, blood circulation, hormonal homeostasis, skin morphology and immunohistochemistry, treatment.