Ostapenco O.V. Morphogenesis of pancreas under the lead compound cumulation in an organism at the use of some during pharmacological correcting remedies. – Manuscript. Dissertation for the degree of candidate of medical sciences in the specialty 14.03.09 – histology, cytology, embryology. – Bogomolets National Medical University, Kyiv, 2008.

Dissertation is devoted to revealing and studying of the morphofunctional changes of pancreas on lead treated male-mace of second generation of BALB/c line. Morphogenesis description of the pancreas has been studied by light and electronic microscopy, historadioautography, morphometrical and mathematical methods.

Fixed, that the chronic lead intoxication in an organism results in the originating of morphological changes in pancreas of animals of all age groups. Atrophic and dystrophic changes in the acinal cells of the exocrine portion of pancreas active proliferation of fibroblast and dystrophy of microcirculatory endothelium were found on the 30-th, 60-th, 90-th days of experimental modulation of lead exposure. The degree and orientation of these changes depends on age of the animal, duration of influence of the lead and also from the conditions of the experiment. The alpha-tocopherol and erbisol can regulate the negative influence of the morphofunctional of mice’s pancreas under the conditions of lead. The erbisol provides the most protective effect on structure and function of pancreas.

Key words: pancreas, lead, alpha-tocopherol, erbisol.