Chegrynyuk L.T Peculiarities of clinical course and treatment of generalized periodontitis in patients with psoriasis. – Manuscript. Dissertation for the degree of candidate of medical sciences in the specialty 14.01.22 – stomatology. – Bogomolets National Medical University, Kyiv, 2011.

The thesis is devoted to peculiarities of the clinical course of generalized periodontitis in patients with psoriasis.

It was revealed high prevalence of periodontal diseases (gingivitis and generalized periodontitis) in patients with psoriasis depends on the age and disease duration in psoriasis.

Generalized periodontitis in this category of persons in most cases characterized by a distinct active progressive course, which was accompanied by a decrease of nonspecific resistance and suppression of local immunity of periodontal tissue.

The existence of the relation between exacerbation of psoriatic disease activity and dystrophic-inflammatory process in periodontal tissue shows the connection between these two diseases.

The high level of production IL-10, TNF-α, IFN-γ in response to staphylococci toxins in patients with generalized periodontitis and psoriasis before treatment and after complex treatment. For this purpose, the first time for the correction of immune disorders in generalized periodontitis and psoriasis with traditional treatment was applied immunomodulator erbisol and vitamin quercetin.

An effective integrated pathogenically justified treatment of patients with generalized periodontitis and psoriasis using immunomodulator erbisol and vitamin product quercetin was developed.

A comparative analysis of immediate and remote results of treatment patients with generalized periodontitis and psoriasis obtained after complex treatment with erbisol and quercetin revealed better results in comparison with traditional methods of treatment.

Key wordsgeneralized periodontitis, psoriasis, superantigens, cytokines, treatment.