Gaistruk N.A. Prophylactics and treatment of feto-placental disorders of women with anemia of pregnancy. – Manuscript. Dissertation for the degree of candidate of medical sciences in the specialty 14.01.01 – obstetrics and gynecology.  – National Pirogov Memorial University, Vinnytsya, 2000.

The thesis work and 10 scientific articles are being defended, said materials containing data on disorders of feto-placental complex of women with anemia of pregnancy, including those of placenta and liver functioning.

The peculiarities of pregnancy course, delivery and postpartum period in women with anemia of pregnancy have been studied (120 pregnant women and women recently confined). It has been obtained that in the case of anemia of pregnancy the significant disorders complicate delivery and postpartum period. The heaviest disorder proves to be bleeding in the third delivery and early postpartum periods.

In women with anemia of pregnancy there are considerable disorders of functioning of feto-placental system, which can be in a sufficient measure determined both on the basis of studying placenta’s morphology and comparison of the character of metabolism processes in organisms of a mother, fetus and in placenta.

In women with anemia of pregnancy, in placenta there is determined high contents of glycosaminoglycans, decrease of glycogen, RNA and DRNA numbers dropping down, lower activity of succinate dehydrogenase and cytochrome oxidase, which monitors serious disorders in metabolism in fetus place tissue. Anemia of pregnancy results in fetus chronic hypoxia and disorders in in-womb life adaptation.

In this thesis we have studied indexes of blood serum ferment activity for anemia in pregnant women and late toxicosis. The results of studying of blood serum ferment activity appeared to be such as for pregnant women anemia of medium and high heaviness (P<0,001, P<0,002).

To provide proper prophylactics and metabolism correction of disordered functions of feto-placental complex of women with anemia of pregnancy, it is expedient to add to treatment, beside glucose, vitamins, iron preparations, the Erbisol antioxidant, which is a hepathropic medicine and a reparant with immunomodulating effect.

Correcting therapy being carried out allows to decrease the number of perinatal mortality, child morbidity, asphyxia number in new-borns, lessen premature delivers, bleeding in the early postpartum period for more than two times.

Key words: anemia of pregnant women, feto-placental system, serum iron, ferments, diagnostics, prevention, treatment.