Litynska T.O. The treatment of patients with alopecia areata with an account for immune status and state of the gastro-intestinal tract. – Manuscript. Dissertation for the degree of candidate of medical sciences in the specialty 14.01.20 – skin and venereal diseases. – Bogomolets National Medical University, Kyiv, 2002.

The dissertation is devoted to studying state of the cellular and humoral components of immune system and the presence of helicobacter gastric infection in patients with different clinical forms and stages of alopecia areata (AA). Based on the results obtained, a combined method for AA therapy was developed with an account for individual features of clinical running, immunological disorders present, and the presence of accompanying chronic infection, H. pylori in particular. It included a set of measures directed towards normalization of immune status with a use of an immunomodulator Erbisol and eradication of helicobacter gastric infection using a triple therapy with omeprasol, clarythromicin and metronidasol.

The therapeutic method proposed ensured regressing clinical signs and symptoms and had a higher efficacy. Thus, a complete cure rate grew up from 10% to 67%, a recurrence rate lowered down from 27.5% to 9.8% with mean follow-up term of 4 years.

Key words: alopecia areata, immune status, Erbisol, helicobacter gastric infection.